Scientific research suggests that by blocking the
NMDA receptors, ketamine prompts the brain to
increase the production of synaptic signaling
proteins in the prefrontal cortex. The prefrontal
cortex is the region of the brain thought to play a
critical role in a person’s ability to regulate
his/her mood. Ketamine appears to
promote the growth of new synapses in the
prefrontal cortex, resulting in greater connectivity
in the brain, while also switching certain
connections on and off. This cascade of events is
thought to be the reason for the rapid antidepressant
effect.
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